Association between type IV collagenα3 H451R (rs11677877A>G) genotypes and the risk of chronic obstructive pulmonary disease (COPD)
| Variables | Cases | Controls | Adjusted OR (95% CI)# | p-value | p-value¶ | ||
| HH | HR+RR | HH | HR+RR | ||||
| Age yrs | |||||||
| ≤60 | 51 (61.4) | 32 (38.6) | 155 (76.4) | 48 (23.6) | 1.93 (1.10–3.39)§ | 0.02 | 0.10 |
| >60 | 162 (71.1) | 66 (28.9) | 139 (76.0) | 44 (24.0) | 1.25 (0.78–2.01)§ | 0.35 | |
| Smoking status | |||||||
| Never | 8 (72.7) | 3 (27.3) | 40 (75.5) | 13 (24.5) | 1.16 (0.27–5.01)ƒ | 0.85 | |
| Ever+ | 205 (68.3) | 95 (31.7) | 254 (76.3) | 79 (23.7) | 1.57 (1.08–2.27)ƒ | 0.02 | 0.29 |
| Smoking pack-yrs+ | |||||||
| ≤33 | 69 (74.2) | 24 (25.8) | 151 (76.3) | 47 (23.7) | 1.15 (0.65–2.06)ƒ | 0.63 | |
| >33 | 136 (65.7) | 71 (34.3) | 103 (76.3) | 32 (23.7) | 1.84 (1.10–3.08)ƒ | 0.02 | 0.09 |
| Severity of COPD | |||||||
| GOLD I–II | 138 (69.7) | 60 (30.3) | 294 (76.2) | 92 (23.8) | 1.33 (0.88–2.01)§,ƒ | 0.18 | |
| GOLD III–IV | 75 (66.4) | 38 (33.6) | 294 (76.2) | 92 (23.8) | 1.62 (1.00–2.61)§,ƒ | 0.04 | 0.38 |
| Age yrs, severity of COPD | |||||||
| ≤60, GOLD I–II | 35 (67.3) | 17 (32.7) | 155 (76.4) | 48 (23.6) | 1.44 (0.73–2.84)§ | 0.30 | |
| ≤60, GOLD III–IV | 16 (51.6) | 15 (48.4) | 155 (76.4) | 48 (23.6) | 3.02 (1.37–6.67)§ | 0.006 | 0.001## |
| >60, GOLD I–II | 103 (70.5) | 43 (29.5) | 139 (76.0) | 44 (24.0) | 1.25 (0.75–2.10)§ | 0.39 | |
| >60, GOLD III–IV | 59 (72.0) | 23 (28.0) | 139 (76.0) | 44 (24.0) | 1.31 (0.69–2.49)§ | 0.40 | |
Data are presented as n (%), unless otherwise stated. OR: odds ratio; CI: confidence interval; GOLD: Global Initiative for Chronic Obstructive Lung Disease. #: for HR+RR versus HH; ¶: test for homogeneity; +: in current and former smokers; §: adjusted for pack-yrs of smoking; ƒ: adjusted for age; ##: compared with all the other groups combined.