Table 2—

Type IV collagenα3 genotypes of chronic obstructive pulmonary disease (COPD) cases and controls, and their association with the risk of COPD

SNPSNP IDGenotypeCases n (%)Controls n (%)p-value#Minor allele frequencyAdjusted OR (95% CI)p-value
CasesControlsp-value#
-1162T>Crs12613226TT154 (49.5)191 (49.5)0.910.300.300.851.00
TC130 (41.8)158 (40.9)0.98 (0.69–1.38)0.90
CC27 (8.7)37 (9.6)0.99 (0.55–1.80)0.98
IVS2+12C>Ars1882435CC101 (32.5)135 (35.0)0.790.420.410.541.00
CA157 (50.5)188 (48.7)1.20 (0.83–1.73)0.33
AA53 (17.0)63 (16.3)1.18 (0.72–1.93)0.51
G162E (G>A)rs6436669GG241 (77.5)307 (79.5)0.350.120.110.741.00
GE68 (21.9)73 (18.9)1.11 (0.74–1.67)0.62
EE2 (0.6)6 (1.6)0.34 (0.06–1.91)0.22
H451R (A>G)rs11677877HH213 (68.5)294 (76.2)0.070.170.130.021.00
HR88 (28.3)84 (21.8)1.44 (1.00–2.11)0.05
RR10 (3.2)8 (2.1)1.99 (0.69–5.76)0.20
HH213 (68.5)294 (76.2)0.021.00
HR+RR98 (31.5)92 (23.8)1.48 (1.03–2.14)0.03
P574L (C>T)rs28381984PP86 (27.7)123 (31.9)0.320.460.440.601.00
PL165 (53.1)183 (47.4)1.39 (0.95–2.04)0.09
LL60 (19.3)80 (20.7)1.25 (0.78–2.01)0.98
*315C>A+rs2070735CC187 (60.1)220 (57.0)0.630.220.240.351.00
CA112 (36.0)147 (38.1)0.88 (0.62-1.24)0.46
AA12 (3.9)19 (4.9)0.55 (0.24-1.26)0.16
  • SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval. #: two-sided Chi-squared test between the cases and controls; : calculated by unconditional logistic analysis, adjusted for age and pack-yrs of smoking; +: nucleotide 315 3′ of the translation termination codon.