Correlation between changes in 6-minute walking distance and changes in haemodynamic parameters and chronotropic response observed after treatment#
| Estimate | R2 | p-value | |
| Resting haemodynamics | |||
| P̄ra mmHg | 0.93 | 0.00 | 0.701 |
| P̄pa mmHg | −1.17 | 0.02 | 0.348 |
| CI L·min−1·m−2 | 64.5 | 0.26 | <0.001 |
| SVi mL·m−1 | 3.7 | 0.16 | 0.006 |
| PVRi mmHg·L−1·min·m−2 | −6.2 | 0.26 | <0.001 |
| Sv,O2 % | 4.7 | 0.16 | 0.017 |
| Exercise haemodynamics | |||
| P̄pa–CI slope mmHg·L−1·min·m−2 | −2.1 | 0.24 | <0.001 |
| Peak P̄pa mmHg | −0.99 | 0.02 | 0.373 |
| Peak CI L·min−1·m−2 | 40.7 | 0.34 | <0.001 |
| Isoflow P̄pa mmHg | −2.8 | 0.54 | <0.001 |
| Peak RVSWi g·m·m−2·beat−1 | 3.1 | 0.18 | 0.003 |
| Chronotropic response during the 6MWT¶ beats·min−1 | 1.9 | 0.18 | 0.005 |
Changes in haemodynamic and exercise parameters correspond to absolute changes. Similar correlation coefficients were obtained when relative changes were considered. P̄ra: mean right atrial pressure; P̄pa: mean pulmonary arterial pressure; CI: cardiac index; SVi: stroke volume index; PVRi: pulmonary vascular resistance index; Sv,O2: mixed venous oxygen saturation; RVSWi: right ventricular stroke work index; 6MWT: 6-min walking test. #: n = 42; ¶: chronotropic response is the difference between peak heart rate during 6MWT and the resting heart rate measured before the 6MWT.