Table 8—

Haplotype association in the cross-sectional study of forced expiratory volume in one second (FEV1)

GeneHaplotype#Low function %High function %Global test p-valuesp-values+
UnadjustedAdjusted§UnadjustedAdjusted§
CSF2-1440A/1622C33.036.9
-1440G/1622C49.744.3nsnsnsns
-1440G/1622T17.320.0nsns
CSF3-1719C/-882G/2176T39.939.9
-1719C/-882A/2176C38.734.20.0040.0270.0070.089
-1719T/-882G/2176C14.016.9ns0.047
-1719C/-882G/2176C7.58.9nsns
-1719C/-882G48.448.8
-1719C/-882A38.734.20.0690.0427nsns
-1719T/-882G14.016.9ns0.058
-882G/2176T39.939.9
-882A/2176C38.734.20.0510.053nsns
-882G/2176C21.525.8ns0.081
  • CSF: colony-stimulating factor; ns: nonsignificant. #: calculated using an Expectation Maximization algorithm from the haplo.stats package for R; : comparing overall haplotype distribution between cases and controls; +: comparing each haplotype between cases and controls, using the most common haplotype as a reference; §: adjusted for age, sex, smoking pack-yrs, research centre and the rate of decline of FEV1 % predicted post-bronchodilator.