Table 1—

Objective features in the five phenotypes of chronic cough and wheeze and an asymptomatic control group

PhenotypeControl#
ABCDE
Subjects n9782584735169
Sex
 Female0.560.520.510.510.270.49
 Male0.440.480.490.490.730.51
Age in 1990 yrs
 0–20.390.540.300.610.360.51
 3–50.610.460.700.390.640.49
Skin-prick tests
 All negative0.810.840.300.910.780.89
 At least one positive0.190.160.700.090.220.11
FEV0.5-1.59±1.41-1.18±1.05-1.80±1.41-1.47±0.57-1.09±0.96-1.33±1.47
Bronchial responsiveness+ PC20-Ptc,O2 g·L−12.42 (1.4–4.1)2.75 (1.5–5.2)1.26 (0.61–2.6)2.32 (1.4–3.9)2.48 (1.4–4.3)3.82 (2.7–6.2)
  • Data are presented as probabilities, mean±sd or geometric mean (interquartile range (IQR)) as estimated by the latent class model, unless otherwise stated. A: persistent cough; B: transient cough; C: atopic persistent wheeze; D: nonatopic persistent wheeze; E: transient viral wheeze; FEV0.5: forced expiratory volume in 0.5 s; PC20-Ptc,O2: provocative concentration of methacholine causing a 20% decrease in transcutaneous oxygen tension. #: children reporting no cough apart from colds and no wheeze ever in both early surveys (1990 and 1992–1994). These subjects were not included in the sample used for model estimation. : sex- and weight-adjusted z-scores 20. The negative mean score in asymptomatic children probably reflects a systematic difference between the present sample and the reference population that is irrelevant for this analysis. +: values based on antilog transformation of model estimated mean and IQR for log PC20-Ptc,O2 23.