Cathepsin H concentrations, activities and inhibitor(cystatin C) concentrations, and ratios expressed on a molar basis
| Control | PAP juvenile | PAP adult | |
| Cathepsin H | |||
| Total nM | 203 (153–254) | 569 (452–686) | 500 (426–574) |
| Activity nM | 7 (2–12) | 243 (88–399) | 467 (172–762) |
| Cystatin C | |||
| Total nM | 1.0 (0.7–1.3) | 5.2 (3.2–7.2) | 5.6 (3.2–8.0) |
| Active cathepsin H % | 3 (1–5) | 46 (19–73) | 85 (40–129) |
| Ratios | |||
| CatH–CatH activity | 85 (24–146) | 7.5 (1.6–13.3) | 15.2 (-13–43.3) |
| CatH activity–CysC | 10.4 (1.3–19.6) | 41.6 (24.5–58.7) | 77.5 (48.2–107) |
| CatH–CysC | 237 (163–310) | 276 (132–420) | 116 (70–163) |
Data are presented as mean (95% confidence interval). PAP: pulmonary alveolar proteinosis; CatH: cathepsin H; CysC: cystatin C.