Table 3—

Fractional areas of extracellular matrix components within the airway smooth muscle in fatal asthma(FA), nonfatal asthma (NFA) and nonasthma control (NAC) cases

Fractional area %p-value#
Elastic fibres
 Large airway17.6±15.5+,§2.2±0.95.5±6.00.001
 Small airway14.2±12.4ƒ3.1±2.88.7±9.70.019
Total collagen
 Large airway7.7±4.35.2±2.17.5±5.90.33
 Small airway9.1±4.86.2±5.17.2±4.50.21
 Large airway6.2±7.02.1±1.80.034
 Small airway5.1±7.84.0±8.70.056
 Large airway2.6±2.31.0±0.70.12
 Small airway5.0±3.12.8±1.60.073
Type-I collagen
 Large airway1.5 (0.3–2.0)0.7 (0.4–1.3)0.63
 Small airway11.0±6.711.0±8.90.38
Type-III collagen
 Large airway0.2 (0.2–0.5)1.0 (0.4–1.5)0.068
 Small airway7.0±7.08.0±4.70.71
  • Data are presented as mean±sd or median (interquartile range), unless otherwise stated. #: ANOVA, unpaired t-test or Mann–Whitney U-test for comparison among the patient groups; : paired t-test or Wilcoxon test for comparison of large airway versus small airway; +: p = 0.002 for FA versus NFA; §: p = 0.007 for FA versus NAC; ƒ: p = 0.019 for FA versus NFA.