Total increase in clearance# over 45 min with each dose of mannitol in the whole right lung and defined regions in 14 subjects with bronchiectasis
| Lung region | Mannitol | ||
| 160 mg | 320 mg | 480 mg | |
| Whole right lung | 6.1 (0.5–11.7)+ | 12.2 (5.7–18.7)*** | 20.4 (12.4–28.4)¶ |
| Central | 2.9 (-6.2–11.9) | 10.2 (-0.3–20.7)*** | 20.5 (9.7–31.5)*** |
| Intermediate | 9.9 (4.6–15.1)*** | 13.5 (8.0–19.0)¶ | 20.3 (13.3–27.4)¶ |
| Peripheral | 8.7 (1.1–16.3)* | 8.0 (2.3–13.7)* | 10.3 (1.1–19.4)** |
Data are presented as total mean absolute clearance (95% confidence intervals). #: compared with clearance on the control study. *, ** and ***: p<0.05, p<0.01 and p<0.001, respectively, versus control; ¶: p<0.0001 versus control; +: p = 0.07 versus control.