Proportion of CD4+ and CD8+ naïve (CD45RA) or memory (CD45R0) T-cells in blood and bronchoalveolar lavage fluid (BALF)
| Never-smokers | Smokers with normal lung function | COPD patients | p-value | |
| CD4+CD45RA+ % | ||||
| Blood | 24.0±3.9 | 24.7±3.0 | 21.9±2.2 | ns |
| BALF | 1.2±0.4 | 1.8±0.4 | 1.4±0.2 | ns |
| p-value | 0.0004 | 0.0001 | 0.0001 | |
| CD4+CD45R0+ % | ||||
| Blood | 57.6±5.0 | 60.2±3.6 | 61.6±3.1 | ns |
| BALF | 95.8±0.7 | 91.7±1.7 | 93.1±1.2 | ns |
| p-value | 0.0001 | 0.0001 | 0.0001 | |
| CD8+CD45RA+ % | ||||
| Blood | 31.4±6.5 | 39.4±3.4 | 41.4±5.3 | ns |
| BALF | 5.4±1.6 | 2.9±0.6 | 10.2±1.5 | <0.001# |
| p-value | 0.014 | 0.0001 | 0.0001 | |
| CD8+CD45R0+ % | ||||
| Blood | 40.2±5.9 | 39.3±3.1 | 36.2±4.3 | ns |
| BALF | 83.2±4.1 | 82.1±2.8 | 71.3±2.9 | <0.05# |
| p-value | 0.0017 | 0.0001 | 0.0001 |
Data are presented as mean±sem, unless otherwise stated. Percentage of CD4+CD45RA+/45R0+ or CD8+CD45RA+/45R0+ refers to the total amount of CD4 or CD8 T-cells, respectively. COPD: chronic obstructive pulmonary disease; ns: nonsignificant. #: for COPD patients versus smokers.