Clinical and haemodynamic data at the time of diagnosis of pulmonary arterial hypertension
| Clinical data | All cases | Incident cases | Prevalent cases | p-value# |
| Subjects n | 578 | 82 | 496 | |
| Female | 77 | 76 | 77 | 0.75 |
| Age yrs | 48±14 (21–83) | 51±14 (21–79) | 48±14 (21–83) | 0.063 |
| WHO functional class III–IV | 80 | 83 | 76 | 0.19 |
| Exercise capacity METs | 3.5±3 | 3.6±1.8 | 3.5±2.0 | 0.87 |
| Haemodynamic data | ||||
| mRAP mmHg | 11±7 | 10±7 | 11±7 | 0.037 |
| mPAP mmHg | 52±14 | 51±12 | 52±14 | 0.30 |
| PCWP mmHg | 10±4 | 10±4 | 10±4 | 0.89 |
| Cardiac index L·min−1·m−2 | 2.3±0.9 | 2.4±0.8 | 2.2±0.9 | 0.07 |
| PA,O2 saturation | 58±12 | 61±10 | 57±12 | 0.015 |
| PVR Woods unit | 12.5±7.3 | 11±5 | 13±7 | 0.027 |
| Acute vasodilator responders | 4.6 | 4.5 | 4.6 | 0.99 |
| Aetiology | 0.12 | |||
| Idiopathic/familial | 48 | 34 | 50 | |
| Connective tissue disease | 30 | 40 | 28 | |
| Congenital heart disease | 11 | 13 | 10 | |
| Portal hypertension | 7 | 9 | 7 | |
| Anorexigens | 3 | 2 | 3 | |
| HIV | 1 | 1 | 1 |
Data are presented as %, mean±sd or mean±sd (range), unless otherwise stated. WHO: World Health Organization; METs: metabolic equivalents; mRAP: mean right atrial pressure; mPAP: mean pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; PA,O2: alveolar oxygen partial pressure; PVR: pulmonary vascular resistance. #: comparisons are for incident versus prevalent cases of pulmonary arterial hypertension.