Table 1—

Clinical characteristics of subjects

Smokers with COPDSubjects with normal lung function
Severe/very severeMild/moderateSmokersNonsmokers
Subjects M/F n5/210/19/03/5
Age yrs65±465±365±363±4
Smoking history pack-yrs47±1143±547±9
FEV1 % pred33±4+74±5ƒ101±4104±6
Ex-/current smokers n4/33/86/3
FEV1/FVC %39±5+65±1ƒ80±279±2
Emphysema score10±14±1
DL,CO# %32±890±15
RV % pred181±2594±18
Pa,O2 mmHg68±6*81±289±389±7
Pa,CO2 mmHg39±241±141±438±1
  • Data are expressed as mean±sem, unless otherwise stated. COPD: chronic obstructive pulmonary disease; M: male; F: female; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; DL,CO: diffusing capacity of the lung for carbon monoxide; RV: residual volume; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension. #: DL,CO was available in seven subjects; : measurements of RV and emphysema score were available in 10 subjects. +: p<0.0001 versus mild/moderate COPD, control smokers and nonsmokers; ƒ: p<0.002 versus control smokers and nonsmokers; *: p<0.05 versus mild/moderate COPD, control smokers and nonsmokers.