Table 4—

Major research gaps in the treatment of cachexia

Why do only some patients become cachectic?
What are the genetic and environmental factors underlying cachexia susceptibility?
What initiates the cachexia process?
What are the sequential molecular steps?
What is the role for nutritional enhancement?
What is the role for supplemental oxygen?
Will suppression of inflammation prevent cachexia?
Will suppression of inflammation reverse cachexia?
What is the role for anabolic hormones?
Is exercise training harmful or beneficial?
What roles do comorbidities play in:
 Susceptibility to cachexia?
 Development of cachexia?
 Management of cachexia?