Toxicity(highest grade per patient) observed for the three initial courses of chemotherapy in assessable patients according to initial performance status (PS)
| Grade III–IV % | Overall | Good PS | Poor PS | p-value |
| Assessable patients n | 474 | 382 | 92 | |
| Leukopaenia | 66 | 64 | 73 | 0.14 |
| Neutropaenia | 70 | 70 | 71 | 1 |
| Thrombopaenia | 20 | 19 | 24 | 0.38 |
| Infection | 7 | 7 | 9 | 0.50 |
| Bleeding | <1 | <1 | 0 | 1 |
| Emesis | 5.5 | 6 | 4 | 0.80 |
| Diarrhoea | 1 | <1 | 3 | 0.05 |
| Skin rash | <1 | <1 | 0 | 1 |
| Alopecia | 23 | 26 | 13 | <0.01 |
| Mucositis | <1 | <1 | 0 | 1 |
| Peripheral neuropathy | <1 | <1 | 2 | 0.17 |
| Ototoxicity | 1 | 0 | 0 | |
| Respiratory | 2 | 2 | 2 | 0.69 |
| Cardiac | 1.5 | 1 | 4 | 0.03 |
| Renal | <1 | <1 | 0 | 1 |