Table 8—

Summary of various chronic obstructive pulmonary disease(COPD) outcomes from patient-reported outcomes, and exacerbations and exercise

Outcome measurePatient-reported outcomesExacerbationsExercise
EQ-5DMRCBDI, TDIDyspnoea-CRQCR10Frequency of exacerbationsSeverity of exacerbationsLab-exercise testingSP-timed walk testsShuttle walk tests
Standardisation of methodologyYesYesYesYesYesYesYesYesYesYes
Statistical frequency distribution
 In the general populationnananananananananaYes
 In COPD patientsnaYesYesYesYesnanananana
ReproducibilitynanaYesnanaYesYesnaYesYes
Relationship with health outcomes
 In the general populationNANANANANANANANANANA
 In COPD patientsNANANANANANANANANANA
Sensitivity to treatment effectNANAYes/noNANAYesNANAYesYes/no
Utility in COPD exacerbationsNANANANANANANANANANA
Influence on comorbiditiesPossiblePossiblePossiblePossiblePossiblePossiblePossibleYesPossibleYes
Utility in multicentre trialsPossiblePossiblePossiblePossiblePossibleYesnaYesYesYes
Measurement requirements
 QuestionnaireYesYesYesYesYesYesYesYesYesYes
 EquipmentNANANANANANANAnanaYes
 Time-consumingna3 minna3 min2 min15–20 min15 min5–10 minna10–20 min
 TrainingYesYesYesNoYesYesYesYesYesYes
Measurement costnaFreeFreeFree/Fee req.nananananaFee req.
Safety issuesNoNoNoNoNoNoNoNoNoNo
Ethical issuesNoNoNoNoNoNoNoNoNoNo
  • EQ-5D: European Quality of Life Scale; MRC: Medical Research Council scale; BDI: baseline dyspnoea index; TDI: translation dyspnoea index; Dyspnoea-CRQ: self-administered dyspnoea domain of the Chronic Respiratory Questionnaire; CR10: 0–10 Category Ratio Scale; SP: self-paced; na: not available; NA: not applicable; Fee req.: licence fee requested.