Table 6—

Summary of various chronic obstructive pulmonary disease(COPD) outcomes from lung function and patient-reported outcomes

Outcome measureLung functionPatient-reported outcomes
FEV1, FVC, FEV6FRC, IC, RVDL,COPa,O2, Sp,O2SF-36NHPSIPCRQSGRQ
Standardisation of methodologyYesYesYesNoYesYesYesYesYes
Statistical frequency distribution
 In the general populationYesYesYesYesYesYesYesNoYes
 In COPD patientsYesnaYesYesYesNoYesYes/noYes
ReproducibilityYesYesYesYesYesYes/noYesYesYes
Relationship with health outcomes
 In the general populationYesNoNoNoNANANANANA
 In COPD patientsYes/noYesYesYesNANANANANA
Sensitivity to treatment effectYesNoYesYesYes/nonaNo/naYesYes
Utility in COPD exacerbationsYesYesNoYesnaYesnaYesYes
Influence on comorbiditiesYesYesYesNoYesYesYesPossiblePossible
Utility in multicentre trialsYesYesYesYesYesYesYesYesYes
Measurement requirements
 QuestionnaireNoNoNoNoNANANANANA
 EquipmentYesYesYesYesYesYesYesNoYes
 Time-consumingYes (moderate)Yes/noYes (moderate)No5 minna10–15 min7–10 min (self-administered standardised), 20 min (individualised)10–15 min
 TrainingYesYesYesYesYesYesYesYesYes
Measurement costVariableVariableVariableVariableVariablenaFee req.Free/Fee req.Free/Fee req.
Safety issuesPossiblePossiblePossibleYes/noNoNoNoNoNo
Ethical issuesNoNoNoNoNoNoNoNoNo
  • FEV1: forced expiratory volume in one second; FVC: forced vital capacity; FEV6: forced expiratory volume in six seconds; FRC: functional residual capacity; IC: inspiratory capacity; RV: residual volume; DL,CO: diffusing capacity of the lung for carbon monoxide; Pa,O2: arterial oxygen tension; Sp,O2: arterial oxygen saturation measured by pulse oximetry; SF-36: 36-item Short-Form Health Questions; NHP: Nottingham Health Profile; SIP: Sickness Impact Profile; CRQ: Chronic Respiratory Questionnaire; SGRQ: St George's Respiratory Questionnaire; na: not available; NA: not applicable; Fee req.: licence fee requested.