Changes during an acute exacerbation of chronic obstructive pulmonary disease(COPD) following early identification (report of the first exacerbation) in various patient-completed questionnaires
| Questionnaire | Baseline | Change from baseline | |||||
| n | Onset | n | 4–8 days | n | 11–15 days | ||
| CCQ | |||||||
| Symptoms | 2.4±1.2 | 89 | 1.0±1.3*** | 97 | 0.8±1.4*** | 101 | 0.04±1.2 |
| Functional state | 2.1±1.3 | 90 | 0.5±1.3*** | 97 | 0.6±1.5*** | 101 | 0.2±1.2 |
| Mental state | 2.0±1.8 | 85 | 0.8±1.7*** | 95 | 0.6±1.6*** | 98 | 0.2±1.6 |
| Total score | 2.2±1.2 | 84 | 0.8±1.1*** | 95 | 0.7±1.2*** | 98 | 0.1±1.1 |
| EQ-5D health score | 66.6±17.8 | 91 | -12.6±19.0* | 96 | -9.0±18.2* | 101 | -1.6±16.2 |
| MRC dyspnoea score | 3.0±0.8 | 97 | 0.5±0.8*** | 104 | 0.3±0.8*** | 116 | 0.0±0.9 |
| ADL score | 32.8±26.9 | 91 | 8.7±31.3¶ | 96 | 10.2±34.2# | 100 | 3.7±30.1 |
Data are presented as mean±sd, unless otherwise stated. CCQ: COPD Control Questionnaire; EQ: EuroQol; MRC: Medical Research Council; ADL: activities of daily living. #: p = 0.004; ¶: p = 0.01; ***: p<0.001.