Table 2—

Variables that predict mortality

MarkerCOPD stage#Cause of mortality
BMII–IVAll cause/respiratory
FEV1I–IVAll cause/respiratory
IC/TLCI–IVAll cause/respiratory
Exercise
V’O2,peakI–IV, tilted towards III–IVSystemic
 6MWTI–IV, tilted towards III–IVSystemic
DyspnoeaII–IVAll cause/respiratory
Decreased chronic Pa,O2III–IVSystemic
BODE0–IVAll cause/respiratory
C-reactive proteinI–IVAll cause
  • COPD: chronic obstructive pulmonary disease; BMI: body mass index; FEV1: forced expiratory volume in one second; IC: inspiratory capacity; TLC: total lung capacity; V’O2,peak: peak oxygen uptake during cardiopulmonary exercise test; 6MWT: 6-min walking test; Pa,O2: arterial oxygen tension; BODE: body mass index (B), obstruction (O), dyspnoea (D) and exercise endurance (E) index. #: Global Initiative for Chronic Obstructive Lung Disease–American Thoracic Society/European Respiratory Society COPD stages.