Table 4—

Results from patients using recombinant human deoxyribonuclease(rhDNase) before bedtime or in the morning after week 1 and 2

rhDNasep-value
BedtimeMorning
After 1 week
 MEF25% % pred47.2±30.045.5±29.90.59
 FVC % pred83.3±18.883.0±16.80.78
 FEV1 % pred75.5±21.475.1±21.60.82
Rint,e0.51±0.220.55±0.270.18
 Oxygen saturation %95.5±1.395.8±1.90.61
 Cough (cs·h−1)2.7±43.7±40.24
After 2 weeks
 MEF25% % pred43.0±28.446.4±28.50.25
 FVC % pred83.0±18.883.1±17.70.97
 FEV1 % pred74.2±21.875.5±20.60.38
Rint,e0.54±0.270.54±0.230.97
 Oxygen saturation %96.1±1.696.2±1.40.78
 Cough (cs·h−1)3.3±53.7±80.85
  • Data are presented as mean±sd unless otherwise stated. MEF25%: maximal instantaneous forced flow when 25% of the forced vital capacity (FVC) remained to be exhaled; % pred: % predicted; FEV1: forced expiratory volume in one second; Rint,e: interrupter resistance exhaled; cs: cough seconds.