Deterministic model prediction of test performance of T-Spot.TB and tuberculin test for the study cohort under different assumptions of T-Spot.TB sensitivity and specificity
| T-Spot.TB | Tuberculin test# | ||||||||||
| Sen. %¶ | Sp. %¶ | LR+ | LR- | PPV % | NPV % | Sen. % | Sp. % | LR+ | LR- | PPV % | NPV % |
| 92.0 | 92.5 | 12.27 | 0.09 | 96.2 | 85.0 | 80.4 | 55.2 | 1.79 | 0.36 | 78.5 | 58.0 |
| 92.0 | 99.0 | 92.00 | 0.08 | 99.5 | 84.5 | 80.4 | 57.9 | 1.91 | 0.34 | 81.3 | 56.5 |
| 92.0 | 86.0 | 6.57 | 0.09 | 92.2 | 85.6 | 80.4 | 52.4 | 1.69 | 0.37 | 75.3 | 59.7 |
| 95.0 | 92.5 | 12.67 | 0.05 | 95.9 | 91.0 | 81.6 | 55.2 | 1.82 | 0.33 | 77.0 | 62.0 |
| 95.0 | 99.0 | 95.00 | 0.05 | 99.5 | 90.6 | 81.6 | 57.9 | 1.94 | 0.32 | 79.9 | 60.6 |
| 95.0 | 86.0 | 6.79 | 0.06 | 91.7 | 91.4 | 81.6 | 52.4 | 1.72 | 0.35 | 73.6 | 63.7 |
| 88.0 | 92.5 | 11.73 | 0.13 | 96.5 | 76.4 | 78.7 | 55.2 | 1.76 | 0.39 | 80.7 | 52.1 |
| 88.0 | 99.0 | 88.00 | 0.12 | 99.6 | 75.7 | 78.7 | 57.9 | 1.87 | 0.37 | 83.2 | 50.6 |
| 88.0 | 86.0 | 6.29 | 0.14 | 93.0 | 77.3 | 78.7 | 52.4 | 1.65 | 0.41 | 77.7 | 53.9 |
Sen.: sensitivity; Sp.: specificity; LR+: positive likelihood ratio; LR-: negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value. #: cut-off of 10 mm; ¶: model assumptions based on the best estimates and upper and lower 95% confidence levels of the sensitivity and specificity of the T-Spot.TB test, as derived from a recently published meta-analysis 8.