Correlates of pulmonary hypertension
| Variable | P̄pa <25 mmHg | P̄pa ≥25 mmHg | P̄pa >40 mmHg | p-value# | p-value¶ |
| Subjects n | 1362 | 932 | 231 | ||
| Demographics | |||||
| Age yrs | 54.0±8.7 | 53.4±8.5 | 49.9±9.2 | 0.040 | <0.0001 |
| Male | 60.9 | 62.8 | 58.7 | 0.360 | 0.560 |
| African-American | 9.0 | 11.8 | 19.1 | 0.030 | <0.0001 |
| BMI kg·m−2 | 27.7±4.8 | 28.7±5.1 | 27.7±5.2 | <0.0001 | 0.870 |
| Pulmonary function | |||||
| FVC % pred | 49.6±15.7 | 48.4±16.7 | 51.4±20.8 | 0.020 | 0.610 |
| FEV1 % pred | 52.7±16.5 | 50.0±16.5 | 51.5±19.0 | <0.0001 | 0.30 |
| Pa,CO2 mmHg | 40.5±5.7 | 41.2±6.9 | 38.7±7.8 | 0.150 | <0.001 |
| 6-min walk distance <45 m | 10.3 | 13.9 | 21.1 | 0.010 | <0.0001 |
| Any need for O2 | 75.9 | 86.0 | 92.8 | <0.0001 | <0.0001 |
| Any need for ≥3 L·min−1 O2 | 37.3 | 51.4 | 65.4 | <0.0001 | <0.0001 |
| O2 used L·min−1 | 2.3±1.9 | 2.9±2.1 | 3.5±2.4 | <0.0001 | <0.0001 |
| Functional status | |||||
| Some or total ADL assistance | 56.7 | 63.3 | 74.4 | 0.001 | <0.0001 |
| Hospitalised | 3.9 | 5.1 | 9.7 | 0.170 | <0.0001 |
| In intensive care unit | 1.4 | 2.3 | 4.0 | 0.140 | 0.010 |
| Comorbid illnesses | |||||
| COPD | 12.4 | 15.7 | 16.2 | 0.030 | 0.0130 |
| Hypertension | 18.1 | 21.6 | 22.8 | 0.040 | 0.011 |
| Diabetes | 10.4 | 13.0 | 7.5 | 0.060 | 0.150 |
| Corticosteroids | 60.5 | 63.4 | 58.4 | 0.170 | 0.560 |
| Haemodynamic monitoring | |||||
| Cardiac index L·min−1·m−2 | 2.8±0.7 | 2.8±0.8 | 2.5±0.9 | 0.82 | <0.0001 |
| Ppcw mmHg | 8.3±4.2 | 12.1±5.5 | 14.0±8.2 | <0.0001 | <0.0001 |
Data are presented as mean±SD or %, unless otherwise stated. P̄pa: mean pulmonary artery pressure; BMI: body mass index; FVC: forced vital capacity; % pred: % predicted; FEV1: forced expiratory volume in one second; Pa,CO2: carbon dioxide arterial tension; ADL: activities of daily living; COPD: chronic obstructive pulmonary disease; Ppcw: pulmonary capillary wedge pressure. #: P̄pa >25 versus ≤25 mmHg; ¶: P̄pa >40 versus ≤25 mmHg. n = 2,525. 1 kPa = 0.133 mmHg.