Table 1—

Influence of acute hypoxia on pulmonary artery smooth muscle cell(PASMC) proliferation

First author [Ref.]Acute hypoxia stimulates PASMC proliferationAcute hypoxia decreases or does not influence PASMC proliferation
O2 %FCS %Cell density on plates cells·cm−2ProliferationO2 %FCS %Cell density on plates cells·cm−2Proliferation
Frid 64310∼10000↑ L1, L3R*30.1∼10000#
310∼10000↓L2, L3S*
Cooper 6551, 2 and 55000↑*025000
Yang 710103.4↑*0106800↓*
Lanner 6035∼500030.1∼5000
Benitz 625–10202500
Tamm 6335↑*
Ambalavanan 661, 2, 3, 5, 7 and 101010000↑1, 5, 7, 10*
Stotz 67514000
Lu 68252500↑*
Frank 691↑*
Preston 70310, 0.12000–4000↑*
Hassoun 72010∼5000
3 and 1010∼5000
Dempsey 5930.1∼25000–50000
Eddahibi 1700.2∼25000↓*
Stiebellehner 61310∼25000
30.1∼25000
Rose 731? (serum-free)
  • FCS: foetal calf serum; L1: inner media, subendothelial layer; L3: outer media; R: rounded epithelioid cells; L2: middle media; S: spindle-shaped cells; ↑: increase of smooth muscle cells proliferation; ↓: decrease of proliferation; ↔: no difference. *: p<0.05, significant change; #: all cells; : hypoxia-selected cells.