Calcitonin(CT) peptides, as hormokines, are a functional entity
| CT | CGRPs | Amylin | ADM | |
| Receptor | CR | CRLR | CR | CRLR |
| RAMP | (2)# | 1 | 1 or 3 | 2 or 3 |
| Second messenger | cAMP, Ca2+ | NO | ? | NO, NF-κB |
| Metabolic effects | ||||
| Insulin resistance | – | + | + | – |
| Effect on β-cells | ± | + | ++ | – |
| Anorectic | ++ | + | ++ | + |
| Gastric protection | – | ++ | + | – |
| Effects on calcium/bone | ++ | ± | + | ± |
| Inflammatory effects | ||||
| Increase plasma in infections | PCT | + | With insulin | + |
| Toxic in sepsis | PCT | +? | – | +? |
| Vasodilation | ± | ++++ | ++ | ++ |
| Pro-inflammatory | ± | ++ | – | + |
| Thermoregulation | – | + | + | + |
| Chrono- and ionotropic | – | ++ | ++ | + |
| Analgesic | ++ | – | + | – |
| Host defence | ||||
| Bactericidal activity | ? | – | – | ++ |
Data represent predominantly experimental results obtained in vitro or in animals (mostly rodents) using supra-physiological dosages. The 114-amino acid form of human procalcitonin (PCT), circulating in high levels during sepsis, is not yet available for experimental purposes. +: positive effect; –: negative effect; ±: mixed effect; +?: questionable positive effect; ?: questionable effect; ++: clear positive effect; ++++: powerful effect. CGRP: CT gene-related peptide; ADM: adrenomedullin; CR: CT receptors; CRLR: CT receptor-like receptors; RAMP: receptor activity-modifying protein; Ca2+: calcium homeostasis NF: nuclear factor. #: not on absolute prerequisite for function of the colcitonin receptor. Compiled and adapted from 2.