Genotype and ozone exposure model of lung function(adjusted for airway size and race/ethnicity)
| Parameter estimates | ||||||
| Males | Females | |||||
| GSTP1 Val105 | GSTM1-null | GSTM1-null/NQO1 Pro187 | GSTP1 Val105 | GSTM1-null | GSTM1-null/NQO1 Pro187 | |
| FEF25-75% | ||||||
| O3 ppb | -0.023±0.002 | -0.024±0.003 | -0.023±0.002 | -0.019±0.002 | -0.020±0.002 | -0.018±0.004 |
| O3·(FEF25-75%/FVC) ppb·s−1 | 0.022±0.001 | 0.022±0.002 | 0.021±0.002 | 0.020±0.001 | 0.020±0.001 | 0.019±0.002 |
| Genotype# | -0.036±0.022¶ | -0.008±0.026 | -0.011±0.024 | -0.001±0.023 | 0.008±0.022 | -0.075±0.035* |
| Adjusted R2 | 0.77 | 0.76 | 0.73 | 0.73 | 0.73 | 0.69 |
| FEF75% | ||||||
| O3 ppb | -0.033±0.003 | -0.031±0.003 | -0.021±0.005 | -0.025±0.003 | -0.026±0.003 | -0.024±0.005 |
| O3·(FEF25-75%/FVC) ppb·s−1 | 0.027±0.002 | 0.026±0.002 | 0.022±0.003 | 0.023±0.002 | 0.024±0.002 | 0.023±0.002 |
| Genotype# | -0.081±0.031* | -0.029±0.034 | -0.013±0.043 | 0.005±0.030 | 0.016±0.029 | -0.054±0.041 |
| Adjusted R2 | 0.74 | 0.72 | 0.74 | 0.70 | 0.70 | 0.71 |
Data are presented are parameter estimate±se. Each model includes height (or height2), weight and lifetime total exposure to NO2- and particles with a 50% cut-off aerodynamic diameter of 10 μm, as determined previously 11, and race/ethnicity. Only O3-specific and genotype parameter estimates are shown; the full model can be found in the online supplement. FEF25–75%: mean forced expiratory flow between 25–75% of FVC; FVC: forced vital capacity; FEF75%: mean forced expiratory flow at 75% of FVC. #: unit of measurement is change in lung function measure for subjects carrying variant allele of each polymorphism. *: p<0.05. ¶: p<0.15.