Exhaled nitric oxide(NO) levels from systemic sclerosis (SSc) patients with and without interstitial lung disease (ILD)
| SSc | p-value | ||
| With ILD | Without ILD | ||
| Subjects n | 33 | 25 | |
| Age yrs | 55.8 (47.3–60.8) | 52.4 (44.7–59.0) | ns |
| Smoker n | 4 | 6 | ns |
| J′aw,NO nL·min−1 | 4.1 (-18.9–13.6) | 18.0 (-0.2–39.6) | <0.05 |
| CA,NO ppb | 7.5 (5.2–11.9) | 4.9 (3.1–7.0) | <0.01 |
| R2 | 0.96 (0.92–0.98) | 0, 95 (0.93–0.98) | ns |
| FeNO50 ppb | 9.3 (5.8–17.1) | 11.1 (6.1–19.0) | ns |
| TLC % pred | 82 (68–95) | 105 (90–107) | <0.001 |
| FVC % pred | 81 (70–97) | 97 (83–115) | <0.01 |
| FEV1 % pred | 83 (74–100) | 92 (83–105) | ns |
| Pa,O2 mmHg | 84 (79–98) | 86 (82–97) | ns |
| DL,CO % pred | 53 (42–66) | 65 (59–82) | <0.01 |
| DL,CO/AV % pred | 73 (58–82.7) | 76 (71–85) | ns |
| Ground-glass score# | 8 (6–12) | 0 (0–0) | <0.001 |
| Reticular score# | 7 (4–9) | 0 (0–0) | <0.001 |
Data are presented as median (1st–3rd quartile), unless otherwise stated. R2: relationship between the elimination rate of NO and exhalation flow rate; FeNO50: fractional exhaled NO concentrationat 50 mL·s−1 constant flow rate; TLC: total lung capacity; % pred: % predicted; FVC: forced vital capacity; FEV1: forced expiratory volume in one second; Pa,O2: arterial oxygen tension; DL,CO: diffusing capacity of the lung for carbon monoxide; AV: alveolar volume; ns: nonsignificant #: maximum of each score is 25. 1 mmHg = 0.133 kPa.