Table 6—

Association between long-term exposure to air pollution and allergen sensitivity at 4 yrs of age for subset of cohort with blood samples, based on early-life risk factors

OR (95% CI)
UnadjustedSubjects nAdjusted#Subjects n
Any allergen positive
 PM2.51.46 (1.13–1.88)*7041.55 (1.13–2.11)*502
 Soot1.37 (1.09–1.71)*7041.45 (1.11–1.91)*502
 NO21.27 (1.03–1.55)*7041.32 (1.03–1.70)*502
Any indoor allergen positive
 PM2.51.14 (0.82–1.57)7321.03 (0.69–1.55)524
 Soot1.12 (0.85–1.49)7321.02 (0.71–1.46)524
 NO21.01 (0.78–1.32)7320.97 (0.69–1.36)524
Any outdoor allergen positive
PM2.50.92 (0.59–1.44)6850.93 (0.54–1.58)488
Soot0.91 (0.62–1.36)6850.95 (0.59–1.52)488
NO20.94 (0.66–1.36)6850.92 (0.59–1.43)488
Any food allergen positive
 PM2.51.59 (1.20–2.11)*7081.75 (1.23–2.47)*506
 Soot1.50 (1.18–1.92)*7081.64 (1.21–2.23)*506
 NO21.41 (1.13–1.76)*7081.49 (1.13–1.97)*506
Total IgE >100 IU·mL−1
 PM2.50.99 (0.75–1.30)7380.84 (0.59–1.18)529
 Soot0.95 (0.75–1.21)7380.80 (0.59–1.09)529
 NO20.97 (0.77–1.21)7380.81 (0.60–1.09)529
  • OR: odds ratio; CI: confidence interval; PM2.5: particles with a 50% cut-off aerodynamic diameter of 2.5 μm; NO2: nitrogen dioxide; Ig: immunoglobulin. #: Adjusted for confounders listed in table 3 from earliest year available (instead of at 4 yrs) i.e. smoking in the home, gas stove, unvented gas water heater, any other siblings and any mould or pets in home and mothers' age at time of birth, but not region. ORs are calculated for an interquartile range increase in annual average concentration at birth address. *: Significant association, p<0.05.