Table 1—

Demographic and clinical characteristics from patients with ventilator-associated pneumonia (VAP) due to multiple drug-resistant Acinetobacter spp. or Pseudomonas aeruginosa susceptible to carbapenem (Carb-S) and susceptible to colistin only (Col-S)

Subjects n3031
Age yrs61.3±17.855.3±19.50.142
APACHE II18.2±6.920.1±8.40.548
Creatinine 10 days after VAP onset mg·dL−11.21±0.891.32±1.290.754
Overall hospitalisation days23 (17–28)37 (25–70)<0.001
Overall ICU stay days21 (16–23)30 (19–64)<0.001
Days on mechanical ventilation16 (10–22)24 (14–55)<0.001
Appropriate empiric antibiotic therapy24170.056
Overall mortality13 (45.1)16 (51.6)0.696
Characteristics present at VAP onset
 Creatinine at the time of VAP diagnosis mg·dL−11.31±0.921.42±1.450.749
 Days on mechanical ventilation7 (5–10)16 (12–34)<0.001
 Days elapsed from admission to VAP diagnosis6 (1–9)15 (10.5–28.5)<0.001
 Days on prior antibiotics5.0±3.113.3±7.1<0.001
 Previous episode of VAP4 (12.5)16 (51.6)0.004
 Prior antimicrobial therapy22 (73.3)30 (96.8)0.026
 Prior use of carbapenems0 (0)13 (41.9)<0.001
  • Data are presented as mean±sd, mean (range) or n (%), unless otherwise stated. APACHE: Acute Physiology and Chronic Health Evaluation; ICU: intensive care unit.