Table 12—

Health-related quality of life with bilevel use in chronic obstructive pulmonary disease

First author [Ref.]Trial lengthQuestionnaireRx/CLOutcome dataComments
 Clini 232 yrsSGRQ at baselineRx66±14Reduction in scores show trend for improvement in both groups primarily due to improvement in symptoms
SGRQ at 24 monthsRx62.7±13.3
MRF-28Significant improvement in bilevel NIPPV group only (data presented graphically only)*
 Garrod 248 weeksCDRQRx68.1±20.9 to 92.2±17.0***CRDQ total score for Bilevel NIPPV and exercise versus exercise only groups
CL73.3±22.4 to 85.1±23.9*
 Meecham Jones 296 monthsSGRQRx60±26.2***
  • Data are presented as mean±sd. Rx: treatment; CL: control; RCT: randomised controlled trial; SGRQ: St. George's Respiratory Questionnaire (lower score reflects improvement); MRF-28: Maugeri Foundation Respiratory Failure Questionnaire; CRDQ: Chronic Respiratory Disease Questionnaire; NIPPV: noninvasive positive pressure ventilation. *: p<0.05; ***: p<0.001.