Table 4—

Lung function and 6-min walking distance at baseline and at 12 weeks

BaselineWeek 12
Subjects n1111
TLC % pred53.64 (45.20–62.08)54.73 (44.87–64.58)
VC % pred54.82 (45.28–64.36)51.36 (38.35–64.38)
FVC % pred55.73 (45.42–66.04)52.18 (38.32–66.05)
DL,CO % pred36.73 (30.07–43.39)33.27 (24.65–41.89)
DL,CO % pred for alveolar ventilation53.09 (40.57–65.61)51.73 (38.33–65.12)
6-min walking distance m320.9 (232.96–408.84)302.9 (205.01–400.79)*
  • Data are presented as mean (95% confidence interval), unless otherwise stated. One patient had no post-baseline assessment and was not included in the analyses; the two patients who died were given the worst value at week 12. TLC: total lung capacity; % pred: % predicted; VC: vital capacity; FVC: forced vital capacity; DL,CO: diffusion capacity of the lung for carbon monoxide. DL,CO was normalised for alveolar ventilation. *: p<0.05.