Table 2—

Gas exchange upon nitric oxide(NO) and bosentan application

ParameterBaselineNOBosentan
Subjects n121212
Shunt flow % of CO8.48 (6.32–10.65)11.05 (5.28–16.82)6.12 (4.64–7.59)**
Low V′/Q′ perfusion % of CO0.33 (−0.22–0.87)1.83 (−0.37–4.02)2.79 (−1.53–7.11)
Normal V′/Q′ perfusion % of CO91.13 (88.96–93.29)87.12 (79.56–94.67)91.08 (86.97–95.19)
Mean V1.06 (0.76–1.36)1.03 (0.80–1.26)1.01 (0.80–1.23)
Mean Q0.69 (0.55–0.83)0.62 (0.49–0.74)0.56 (0.44–0.69)
Log SDV0.62 (0.49–0.74)0.64 (0.51–0.77)0.70 (0.59–0.81)
Log SDQ0.62 (0.50–0.73)0.70 (0.49–0.91)0.76 (0.56–0.95)
VE L·min−16.83 (5.53–8.12)6.59 (5.53–7.65)6.75 (5.50–8.00)
O2 saturation %97.22 (95.99–98.44)95.96 (94.49–97.42)96.29 (94.88–97.71)
  • Data are presented as mean (95% confidence interval), unless otherwise stated, recorded under baseline conditions and subsequent to NO inhalation, or oral bosentan, respectively, by using multiple inert gas elimination technique. Mean perfusion (Q′) and mean ventilation (V′) represent the mean V′/Q′ ratio for perfusion and ventilation, respectively. Log SDQ and Log SDVA represent the dispersion of these data, estimated by the log SD of perfusion and ventilation, respectively. Shunt represents portion of perfusion to nonventilated areas (V′/Q′ 0–0.001). Low V′/Q′ areas represent portion of perfusion to areas with reduced ventilation (V′/Q′ 0.001–0.01). CO: cardiac output; VE: minute ventilation; O2: oxygen. **: p<0.01, determined using paired signed rank test.