Table 2—

Characteristics of the glycosaminoglycan domain-specific antibodies used in the present study

CloneCDR3VHDPGAG[Ref.]
AO4B08SLRMNGWRAHQ347HS#27
HS4C3GRRLKD338HS25
IO3H10AKRLDW17CS+28
IO3H12MKTRLDV346CS28
IO4C2GKQRYS354CS/Hep28
LKN1GIKL125DS§29
  • Clone: anti-glycosaminoglycan antibody clone; CDR3: amino acid sequence of the heavy chain germ line family (VH) complementarity determining region 3 (a major determinant in antigen recognition); DP: gene number; GAG: class of glycosaminoglycan(s) with which the antibody reacts; HS: heparan sulphate; CS: chondroitin sulphate; Hep: heparin; DS: dermatan sulphate. #: recognises highly sulphated HS epitopes (preferred modifications: IdoA, NS, 2OS, 6OS; preferred domain: [IdoA2S-GlcNS,6S]); : recognises highly sulphated HS epitopes (preferred modifications: NS, 3OS, 6OS; preferred domain: [IdoA2S-GlcNS,3S,6S]); +: recognises CS-C epitopes (preferred domain: [GlcA-GalNac,6S]); §: recognises DS epitopes (preferred modifications: 2OS, 4OS, 6OS).