Table 2—

Role of co-stimulatory molecules in the development of allergen-induced immune and airway responses studied in various deficient germline mice

DeficiencyBALF eosinophilsAHRIgETh2 cytokinesTh1 (IFN-γ)[Ref.]
CD28ND96
ND97
CD8095
CD8695
CD80/CD8695
98
ICOSNDND99
NDND100
NDND101
ICOS-LNDNDND102
ND103
OX40NDNDND104
ND105
OX40LNDNDND106
107
ND108
  • BALF: bronchoalveolar lavage fluid; AHR: airway hyperresponsiveness; Ig: immunoglobulin; Th: T-helper cell; IFN: interferon; ICOS: inducible co-stimulatory antigen; ICOS-L: ICOS ligand; OX40: CD134; OX40L: OX40 ligand; ↓: decreased; ↑: increased; ↔: unchanged; ND: not determined.