C▒ | C- | p-value# | RO▒ | RO- | p-value¶ | |
Subjects n | 21 | 19 | 23 | 17 | ||
Demographics | ||||||
Age yrs | 9.1 (4.5) | 9.8 (7.8) | 0.46 | 9.7 (4.3) | 8.9 (8.0) | 0.33 |
Male/female n | 12/9 | 14/5 | 0.45 | 18/5 | 8/9 | 0.09 |
Airway cellularity | ||||||
Lymphocyte % | 3.0 (3.5) | 2.5 (13.8) | 0.77 | 3.5 (7.5) | 2.5 (2.3) | 0.60 |
Neutrophil % | 6.5 (4.3) | 4.0 (8.3) | 0.41 | 4.5 (3.8) | 7.0 (6.3) | 0.01+ |
Macrophage % | 90 (8.1) | 80 (67.0) | 0.67 | 86 (33.0) | 88 (9.7) | 0.41 |
Eosinophil % | 0 (0) | 0 (0) | 0.33 | 0 (0) | 0.0 (0.8) | 0.77 |
Total cell count ×10−6·L−1 | 86 (60) | 46 (169.0) | 0.21 | 59 (108) | 83 (62.5) | 0.25 |
Sensory neuropeptides | ||||||
CGRP ng·L−1 | 2.7 (4.5) | 0 (6.3) | 0.16 | 2.3 (6.7) | 2.7 (3.8) | 0.76 |
Neurokinin A ng·L−1 | 16.2 (8.6) | 17.5 (9.83) | 0.88 | 18.9 (9.0) | 16.2 (6.2) | 0.11 |
Substance P ng·L−1 | 57.8 (43.6) | 49.3 (55.5) | 0.67 | 45.7 (50.7) | 57.8 (54.4) | 0.76 |
Capsaicin sensitivity | ||||||
C2 μM | 14.7 (19.5) | 39 (58.5) | 0.018+ | 19.5 (9.7) | 14.7 (39.0) | 0.17 |
C5 μM | 29.3 (68.2) | 58.5 (58.5) | 0.13 | 39 (29.2) | 29.3 (117.0) | 0.06 |
Data are presented as n or median (interquartile range given as the 75th quartile minus the 25th quartile), unless otherwise indicated. CGRP: calcitonin gene-related peptide; C2: the concentration of capsaicin that stimulated ≥2 coughs; C5: the concentration of capsaicin that stimulated ≥5 coughs. #: comparisons between C+ and C- groups using the Mann–Whitney U-test; ¶: comparisons between RO+ and RO- groups using the Mann–Whitney U-test; +: p-value is significant.