Variable | Smokers | Nonsmokers | p-value |
Subjects n | 12 | 4 | |
Demographic | |||
Age yrs | 52.4±9.2 | 46.75±20.5 | 0.4 |
Male/female | 9/3 (75/25) | 0/4 (0/100) | 0.01 |
Pulmonary function testing | 7 | 2 | |
Obstructive pattern | 7 (100) | 2 (100) | 0.5 |
Chest radiograph | 12 | 3 | |
Linear densities | 10 (90) | 2 (50) | 0.4 |
Bullae | 11 (91) | 0 (0) | 1.0 |
HRCT | 6 | 2 | |
Ground-glass opacities | 3 (50) | 0 (0) | 0.5 |
Reticular | 3 (50) | 1(50) | 1.0 |
Bullae | 3(50) | 1(50) | 1.0 |
Cyst | 1(20) | 1(50) | 1.0 |
Emphysema | 2(50) | 0(00) | 1.0 |
Data are presented as n, mean±SD or n (%). HRCT: high-resolution computed tomography. Surgical lung biopsy results were available in 14 cases, all 14 showed fibrosis and 13 showed interstitial inflammation (93%). Honeycomb cysts were present in three cases (23%).