Table 2—

Time course of inflammatory markers at exacerbation of chronic obstructive pulmonary disease

MarkerBaselineExacerbation onsetp-value baseline–onsetDay 7p-value baseline–day 7Day 14p-value baseline–day 14Day 35p-value baseline–day 35
Sputum
 IL-6 pg·mL−1112 (40–219)161 (86–308)0.03144 (64–226)0.31124 (83–236)0.95216 (76–319)0.63
 IL-8 pg·mL−12941 (1913–3808)3276 (2285–4129)0.132653 (1630–3912)0.092296 (1667–3424)0.123305 (2400–4118)0.67
Serum
 IL-6 pg·mL−15.6 (3.1–8.4)12.1 (4.0–19.9)<0.013.9 (1.6–6.4)<0.014.9 (2.6–8.7)0.165.8 (3.2–9.0)0.38
 CRP mg·L−16.5 (3.8–11.8)10.9 (5.5–34.2)<0.015.3 (3.5–9.4)0.954.0 (2.3–9.6)0.106.8 (3.6–11.6)0.42
  • Data are presented as median (interquartile range), unless otherwise stated. IL: interleukin; CRP: C-reactive protein.