NTM-positive | NTM-negative | |
Patients | 10 | 88 |
Age yrs | 59.4±3.3 | 59.3±1.4 |
Male | 4 | 28 |
FEV1 % pred | 59.9±8.6 | 63.9±2.3 |
FVC % pred | 86.0±6.9 | 85.8±2.0 |
CFTR mutations | 2× ΔF508 het 7× none 1× not known | 2× ΔF508 het 2× R117h het 73× none 11× not known |
Colonisation | ||
P. aeruginosa | 6 | 41 |
H. influenzae | 0 | 4 |
S. aureus | 0 | 2 |
Long-term antibiotics | ||
Colomycin (nebulised) | 5 | 20 |
Gentamicin (nebulised) | 0 | 3 |
Amoxicillin (oral) | 2 | 3+1 nebulised |
Azithromycin (oral)# | 0 | 1 |
Ciprofloxacin (oral)# | 0 | 1 |
Clarithromycin (oral)# | 0 | 4 |
Doxycycline (oral)# | 2 | 11 |
Metronidazole (oral) | 0 | 1 |
Flucloxacillin (oral) | 0 | 1 |
Trimethoprim (oral) | 0 | 1 |
None | 2 | 43 |
Data are presented as n or mean±sem. FEV1: forced expiratory volume in one second; % pred: percentage of predicted value; FVC: forced vital capacity; CFTR: cystic fibrosis transmembrane regulator; P. aeruginosa: Pseudomonas aeruginosa; H. influenzae: Haemophilus influenzae; S. aureus: Staphylococcus aureus; het: heterozygous. #: antibiotic can have antimycobacterial activity. Two NTM-negative patients were taking long-term colomycin and azithromycin and one was taking long-term colomycin and doxycycline. One NTM-positive patient was taking long-term colomycin and doxycycline.