Table 3—

Factor analysis of repertoires of immunoglobulin(Ig)G and IgM from the sera of idiopathic pulmonary arterial hypertension (IPAH) patients, systemic scleroderma (SSc) patients with or without pulmonary arterial hypertension (PAH) and their respective controls, on normal human fibroblasts and human epithelial (HEp)-2 cell antigens

Antigen source	Isotype		Factor	PAH versus controls		IPAH versus controls		SSc PAH versus controls
				Molecular weights kDa	p-value	Molecular weights kDa	p-value	Molecular weights kDa	p-value
	IgG	1		30, 35, 40, 60	<0.001^#	30, 35, 40, 60	<0.001^#	30, 35, 40, 60, 95	0.557
		2		25, 95	<0.001	25, 95	<0.001^#	25, 60	0.084
Fibroblasts	IgM	1		65, 70	0.003^#	25, 30, 35, 95	0.008^#	25, 30, 50, 75, 85	0.275
		2		35, 40	0.003^#	40, 70	0.023^#	25, 35, 40	0.922
		3		70, 95	0.456	50, 75, 85	<0.001^#	70, 95	0.922
	IgG	1		25, 30, 35, 50, 75, 85	0.367	65, 70	0.367	65, 70	0.367
		2		35,40	0.795	45, 65	0.795	45, 65	0.795
		3		70, 95	0.122	25, 35	0.122	25, 35	0.122
HEp-2 cells	IgM	1		35, 45, 50, 73, 75	0.1	30, 45, 50, 73, 75	0.06	55, 65, 70, 75	0.37
		2		55, 65, 70	0.27	25, 30	0.24	25, 30, 35, 45, 50, 73, 75	0.85
		3		25, 30	0.63	55, 65	0.23

^#: level of significance of the comparison of the factor scores of patients with controls using a paired Wilcoxon test.