Table 2—

Characteristics of patients remaining on bosentan monotherapy

IPAHPAH-SSDp-value
Subjects n2928
Age yrs51±1465±110.001
Race white23 (79)22 (79)ns
Sex female23 (79)25 (89)ns
NYHA FC at diagnosis I/II versus III/IV8/2111/28ns
6MWD m361±183275±51ns
RAP mmHg9±612±5ns
mPpa mmHg53±1246±12ns
CI L·min−1·m−22.2±0.52.2±0.6ns
PVR Wood unit11±59±4ns
Ppcw mmHg11±412±3ns
Warfarin use22 (76)17 (62)ns
Calcium channel blocker use3 (10)9 (32)0.04
Digoxin use3 (10)2 (7)ns
  • Data are presented as mean±sd or n (%), unless otherwise stated. IPAH: idiopathic pulmonary arterial hypertension (PAH); PAH-SSD: scleroderma-associated PAH; NYHA: New York Heart Association; FC: functional class; 6MWD: 6-min walk distance; RAP: right atrial pressure; mPpa: mean pulmonary arterial pressure; CI: cardiac index; PVR: pulmonary vascular resistance; Ppcw: pulmonary capillary wedge pressure; ns: nonsignificant.