Table 2—

Diagnostic criteria for diffuse panbronchiolitis

1.Persistent cough, sputum and exertional dyspnoea
2.History of chronic paranasal sinusitis
3.Bilateral diffuse small nodular shadows on a plain chest radiography film or centrilobular micronodules on chest computed tomography images
4.Coarse crackles
5.FEV1/FVC <70% and Pa,O2 <80 mmHg
6.Titre of cold haemagglutinin ≥64
  • FEV1: forced expiratory volume in one second; FVC: forced vital capacity; Pa,O2: arterial oxygen tension. Cases definitely established should fulfil criteria 1, 2 and 3, along with at least two of criteria 4, 5 and 6. These parameters are useful for carrying out an epidemiological analysis. In countries in which the disease is very rare, surgical lung biopsy is required to make a diagnosis. Criteria are taken from a working group of the Ministry of Health and Welfare of Japan 67. 1 mmHg = 0.133 kPa.