Diagnostic criteria for diffuse panbronchiolitis
| 1. | Persistent cough, sputum and exertional dyspnoea |
| 2. | History of chronic paranasal sinusitis |
| 3. | Bilateral diffuse small nodular shadows on a plain chest radiography film or centrilobular micronodules on chest computed tomography images |
| 4. | Coarse crackles |
| 5. | FEV1/FVC <70% and Pa,O2 <80 mmHg |
| 6. | Titre of cold haemagglutinin ≥64 |
FEV1: forced expiratory volume in one second; FVC: forced vital capacity; Pa,O2: arterial oxygen tension. Cases definitely established should fulfil criteria 1, 2 and 3, along with at least two of criteria 4, 5 and 6. These parameters are useful for carrying out an epidemiological analysis. In countries in which the disease is very rare, surgical lung biopsy is required to make a diagnosis. Criteria are taken from a working group of the Ministry of Health and Welfare of Japan 67. 1 mmHg = 0.133 kPa.