Table 3—

Cytokines investigated in pleural effusions and corresponding mesothelioma cell lines

Detected#Mean PF±sd:mean SN±sd
PF ↑↑
 HGF1.50±1.50:0
 MIP-1δ1.67±0.52:0*
 MIP-3α0.83±1.33:0
 NAP-22.33±0.52:0*
 PARC3.50±0.55:0*
PF
 Ang3.17±0.41:2.00±0*
 Eotaxin-20.33±0.84:0
 IGFBP-11.50±1.05:0.50±0.57
 IGFBP-21.83±0.98:1.25±1.5
 IL-120.17±0.41:0
 IP-101.00±0.89:0.75±1.50
 Leptin0.50±0.84:0
 MIF0.67±1.04:0.25±0.5
 OSM0.17±0.41:0
 PIGF0.83±0.75:0.50±1.00
PFSN
 Osteoprotegrin0.83±0.75:0.75±0.50
 VEGF0.67±0.82:0.75±0.96
 MCP-12.33±0.51:2.50±1.73
 TGF-β20.17±0.41:0.25±0.50
 ENA-780.50±1.22:0.50±1.00
 TIMP-12.67±0.51:2.50±1.29
 IL-64.50±0.84:3.50±2.38
 MIP-1β1.00±0.63:0.75±1.50
SN
 BDNF0:0.25±0.50
 IGFBP-30.33±0.51:0.75±0.50
 IGFBP-40.83±0.75:1.25±0.96
 TIMP-22.50±0.55:3.25±0.50
 IL-83.66±1.51:4.25±0.50
SN ↑↑
 GRO1.50±0.84:2.75±0.5*
 RANTES0.17±0.41:1.25±0.96
  • For cytokine abbreviations see table 1. PF: pleural fluid; SN: cell line supernatant. ↑↑: strong increase; ↑: moderate increase; ↔: equally expressed in PF and SN. #: cytokines that were not detected were BLC, Ck-β-8-1, EGF, eotaxin, eotaxin-3, FGF-4 to -9 Flt-3 ligand, fractalkine, GCP-2, GCSF, GDNF, GM-CSF, GRO-α, I-309, IFN-γ, IGF-1, IL-1α, -1β and -2 to -16, LIF, LIGHT, MCP-2 to -4, MCSF, MDC, MIG, NT-3 and -4, PDGF-B, SCF, SDF-1, TARC, TGF-β1 and -β3, TNF-α and -β, and TPO. *: p<0.05.