Table 5—

Comparison of 155 chronic obstructive pulmonary disease(COPD) and 183 non-COPD patients with severe community-acquired pneumonia depending of the modality of ventilation

VariableCOPD patientsNon-COPD patients
Initial intubationFailure to NIVSuccessful NIVp-value#Initial intubationFailure to NIVSuccessful NIVp-value#
Subjects10524261222536
Age yrs68.9±8.669.6±8.760.1±10.80.00158.5±16.462.3±16.655.4±17.20.13
APS score13.7±11.515.1±6.67.7±6.7<0.00114.1±8.314.0±6.68.1±5.8<0.001
ICU mortality rate41 (39)12 (50)0<0.00141 (33.6)9 (36.0)3 (8.3)0.01
LOS for survivors days17.7±14.518.5±11.18.2±7.1<0.00125.7±19.731.1±26.29.5±5.5<0.001
Main comorbidities
 Smoker67 (63.8)16 (66.7)14 (53.8)0.5251 (41.8)8 (32.0)12 (33.3)1.00
 Chronic heart disease47 (44.8)14 (58.3)7 (26.9)0.0530 (24.6)7 (28.0)8 (22.2)0.76
 Alcoholism32 (30.5)10 (41.7)7 (26.9)0.4229 (23.8)8 (32.0)6 (16.7)0.21
 Diabetes mellitus32 (30.5)4 (16.7)4 (15.4)0.7925 (20.5)6 (24.0)10 (27.8)0.77
Positive blood culture13 (12.4)4 (16.7)5 (19.2)0.8923 (18.9)8 (32.0)4 (11.1)0.05
Bilateral pneumonia51 (48.6)8 (33.3)3 (11.5)0.0977 (63.1)19 (76.0)18 (50.0)0.06
Empyema2 (1.9)01 (3.8)1.09 (7.4)1 (4.0)4 (11.1)0.65
Presence of P. aeruginosa9 (8.6)3 (12.5)00.101 (0.8)00
  • Data are presented as n, mean±sd or n (%), unless otherwise stated. NIV: noninvasive ventilation; APS: acute physiologic score of Acute Physiology And Chronic Health Evaluation II score; ICU: intensive care unit; LOS: length of stay; P. aeruginosa: Pseudomonas aeruginosa. #: p-value for comparison between patients with failure to NIV and successful NIV.