Table 1—

Changes in gene expression after inhalation of ultrafine particles for 4 h and 24 h

IdentifierName/descriptionGene symbol4 h24 h
Fold induction
 M12571Heat shock protein, 1AHsp1a4.0#1.2
 L40406Heat shock protein, 105 kDaHsp1052.6#1.1
 AF101164CEA-related cell adhesion molecule-2Ceacam22.2#1.3
 AW124318Suppression of tumorigenicity-13St132.2#1.0
 U27830Stress-induced phosphoprotein-1Stip12.0#1.2
 U16162Prolyl 4-hydroxylase alpha(I)-subunitP4ha12.0#1.1
 U2392Osmotic stress protein-94Osp942.0#0.9
 X03505Serum amyloid A-3Saa31.15.4#
 X69620Inhibin beta-BInhbb2.53.8#
 X13986Osteopontin, secreted phosphoproteinSpp11.13.4#
 M34141Prostaglandin-endoperoxide synthase-1Ptgs11.03.0#
 AW230891Leucine-rich alpha-2-glycoprotein-1Lrg11.42.8#
 V00755Tissue inhibitor of metalloproteinases-1Timp11.32.4#
 M64086Spi2 proteinase inhibitor (spi2/eb4)Serpina3n1.12.4#
 M62470Thrombospondin-1Thbs13.0+2.4#
 X8162724p3, lipocalin2Lcn21.02.4#
 L41352AmphiregulinAreg1.22.4#
 AV300608SH2 domain binding protein-1Sh2bp10.82.2#
 M26071Coagulation factor IIIF31.12.2#
 AF023919PK-120 precursoritih-40.92.2#
 M15131Interleukin-1βIL1β0.92.0#
 M36120Keratin complex-1, acidic gene-19Krt1-191.02.0#
 M35970Expressed in nonmetastatic cells-1Nme10.82.0#
 X16834Galectin-3, Mac-2Lgals31.02.0#
Fold repression
 K02588Cytochrome P450,1a1Cyp1a11.22.6#
 X58289Protein tyrosine phosphatase, receptor type BPtprb1.62.4#
 Y07693Nuclear factor I/CNfic1.22.4#
 D38216RyR1 skeletal muscle ryanodine receptorRyr11.02.2#
 X84037E-selectin ligand-1, golgi apparatus protein-1Glg11.42.0#
 AI152867Eukaryotic translation initiation factor-2CEif2c21.62.0#
  • #: genes induced or repressed two-fold or more after 4-h or 24-h ultra-fine carbon particle inhalation; : excluded from analysis because absent in test sample (see Methods section); +: excluded from analysis because fold change between clean air controls (4 h and 24 h) two-fold or more.