Table 2—

Effects of lipopolysaccharide on neutrophil infiltration, lactate dehydrogenase(LDH) activity and terminal deoxynucleotide transferase-mediated dUTP nick-end labelling (TUNEL)-positive cells in whole sections and inflammatory foci (IF)

ParametersControl4 h12 h24 h36 h48 h60 h72 h
Neutrophil cells·mL-1 BAL0.28 (0.55–0.21)0.3 (0.43–0.12)**0.71 (1.15–0.23)**1.26 (1.41–0.87)**2.94 (4.37–2.49)**4.24 (6.47–2.09)**4.54 (5.21–3.23)**2.51 (3.54–0.75)
LDH activity0.00 (0.01–0.00)3.31 (4.04–2.90)6.33 (7.28–2.33)6.83 (9.00–4.75)**7.49 (12.29–6.12)**7.82 (9.66–2.96)**3.59 (5.40–2.16)**0.83 (1.18–0.06)**
TUNEL whole sections1.28 (6.27–0.89)31.62 (47.01–17.09)*129.81 (210.90–66.67)*290.00 (585.64–71.79)**347.33 (767.58–147.14)*361.00 (489.58–253.91)*193.15 (552.56–159.62)*227.56 (453.33–48.72)*
TUNEL IF0.00 (0.00–0.00)0.00 (0.00–0.00)223.08 (350.00–125.64)*703.85 (747.44–419.23)*647.14 (997.40–335.94)*842.45 (878.91–395.83)*392.31 (624.79–280.77)*325.64 (757.69–164.10)*
  • Data are presented as median (range). BAL: bronchoalveolar lavage. *: p<0.05; **: p<0.01 versus control.