Table 1—

Characteristics by ventilation stages with spirometric data after 1, 3, 5 and 7 yrs of follow-up

CharacteristicsNIPPVMIPPV1 yr3 yrs5 yrs7 yrsANOVA
Subjects n424235281713
Age yrs***19.4±4.223.5±4.424.8±4.727.1±5.029.2±4.932.5±4.4a, c, d, e
Height cm164±8164±8163±8163±8163±8164±8
Weight kg52±1547±1649±1349±1347±1146±12
VC mL***1016±399534±200582±198488±178412±173354±129a, f
VC % pred***21±811±413±411±49±48±3a
MIP cmH2O***29±1116±515±512±58±36±2a, c ,d, e
VT mL***281±87217±64199±46181±57168±58137±75a, e
VE mL***5692±16575027±13394688±12714466±15254292±14583396±1772a, e
VE,alv mL***3398±10582792±9162509±8482263±10112057±11121391±1278a, e, f
Free time h***24.0±015.7±1.12.9±1.82.1±1.81.2±1.60.5±0.6a, b, c, d, e
Diurnal Pt,CO2mmHg62±1743±1039±1039±1043±12b
Symptom score per 7 pts3.2±1.60.8±1.1b
  • Data are presented as mean±sd, unless otherwise stated. NIPPV: start of nocturnal nasal intermittent positive pressure ventilation; MIPPV: start of diurnal mouthpiece intermittent positive pressure ventilation; BMI: body mass index; VC: vital capacity; % pred: percentage of predicted; MIP: maximal inspiratory pressure; VT: tidal volume; RR: respiratory rate; VE: spontaneous minute expiratory ventilation; VE,alv: alveolar minute ventilation; Pt,CO2: transcutaceous CO2 tension; a: NIPPV/MIPPV; b: MIPPV/1 yr; c: MIPPV/3 yrs; d: MIPPV/5 yrs; e: MIPPV/7 yrs; f: 1 yr/7 yrs. #: p = 0.005; ***: p<0.001. 1 mmHg = 0.133 kPa.