Table 2—

Anthropometric and lung function data of subjects with cystic fibrosis, stratified according to the three-point expiratory flow-limitation score

NFLFLsupineFLseated
Subjects n681618
M/F subjects n36/327/915/3*,#
Age yrs28.2±6.628.8±6.033.1±9.8*
BMI kg·m−221.5±3.220.4±2.221.8±2.7
FEV1 % pred57.3±15.640.5±11.6*28.5±7.7*,#
FVC % pred75.6±17.462.4±13.8*50.4±10.1*
FER0.65±0.100.57±0.14*0.48±0.11*
FEF25–75 % pred30.5±17.114.8±7.9*10.4±5.0*
IC seated % pred84.6±19.475.4±15.161.4±16.9*
IC supine % pred87.1±20.071.2±14.7*57.3±16.9*
MRC score1.0±0.71.4±0.62.2±1.0*,#
RV % pred152±61176±40219±79*
FRC % pred120±15112±14150±20*,#
TLC % pred97±898±4105±8*
RV/TLC % pred158±56174±57225±47*
  • Data are presented as mean±sd, unless otherwise stated. NFL: not flow limited; FLsupine: flow limited in the supine position; FLseated: flow limited in both the seated and supine positions; M: male; F: female; BMI: body mass index; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; FER: forced expiratory ratio; FEF25–75%: forced expiratory flow rates between 25–75% of FVC; IC: inspiratory capacity; MRC: Medical Research Council; RV: residual volume; FRC: functional residual capacity; TLC: total lung capacity. : measured in 12 of the NFL subjects, seven of the FLsupine subjects and 11 of the FLseated subjects. *: p<0.05 versus not flow-limited group; #: p<0.05 versus flow-limited supine group.