NFL | FLsupine | FLseated | |
Subjects n | 68 | 16 | 18 |
M/F subjects n | 36/32 | 7/9 | 15/3*,# |
Age yrs | 28.2±6.6 | 28.8±6.0 | 33.1±9.8* |
BMI kg·m−2 | 21.5±3.2 | 20.4±2.2 | 21.8±2.7 |
FEV1 % pred | 57.3±15.6 | 40.5±11.6* | 28.5±7.7*,# |
FVC % pred | 75.6±17.4 | 62.4±13.8* | 50.4±10.1* |
FER | 0.65±0.10 | 0.57±0.14* | 0.48±0.11* |
FEF25–75 % pred | 30.5±17.1 | 14.8±7.9* | 10.4±5.0* |
IC seated % pred | 84.6±19.4 | 75.4±15.1 | 61.4±16.9* |
IC supine % pred | 87.1±20.0 | 71.2±14.7* | 57.3±16.9* |
MRC score | 1.0±0.7 | 1.4±0.6 | 2.2±1.0*,# |
RV % pred¶ | 152±61 | 176±40 | 219±79* |
FRC % pred¶ | 120±15 | 112±14 | 150±20*,# |
TLC % pred¶ | 97±8 | 98±4 | 105±8* |
RV/TLC % pred¶ | 158±56 | 174±57 | 225±47* |
Data are presented as mean±sd, unless otherwise stated. NFL: not flow limited; FLsupine: flow limited in the supine position; FLseated: flow limited in both the seated and supine positions; M: male; F: female; BMI: body mass index; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; FER: forced expiratory ratio; FEF25–75%: forced expiratory flow rates between 25–75% of FVC; IC: inspiratory capacity; MRC: Medical Research Council; RV: residual volume; FRC: functional residual capacity; TLC: total lung capacity. ¶: measured in 12 of the NFL subjects, seven of the FLsupine subjects and 11 of the FLseated subjects. *: p<0.05 versus not flow-limited group; #: p<0.05 versus flow-limited supine group.