Lean subjects | Obese subjects | Mild OSA | Moderate-to-severe OSA | |
Subjects n | 12 | 18 | 20 | 20 |
Age yrs | 47.9±2.2 | 48.1±2.4 | 50.3±1.5 | 49.3±3.5 |
Blood pressure mmHg | ||||
Systolic | 126.8±3.0 | 130.1±3.3 | 129.4±2.5 | 132.0±3.9 |
Diastolic | 73.5±2.1 | 72.8±2.6 | 75.4±2.0 | 76.1±3.0 |
BMI kg·m-2 | 22.9±0.4 | 27.7±0.9# | 27.2±0.7¶ | 28.9±0.6+ |
Waist cm | 74.3±3.1 | 88.4±1.9# | 89.5±1.0¶ | 90.5±1.8+ |
Waist/hip ratio | 0.78±0.01 | 0.89±0.01# | 0.87±0.01¶ | 0.92±0.02+ |
Total cholesterol mg·dL-1 | 200.6±7.4 | 201.5±8.8 | 202.0±6.2 | 206.4±8.2 |
HDL cholesterol mg·dL-1 | 45.5±3.3 | 46.6±1.7 | 41.4±1.4¶,§ | 38.9±1.3+,ƒ |
LDL cholesterol mg·dL-1 | 120.0±5.5 | 131.2±3.9 | 135.0±2.5¶ | 136.1±2.9+ |
Glucose mg·dL-1 | 85.6±7.3 | 89.6±8.1 | 91.2±6.5 | 93.1±8.5 |
Triglyceride mg·dL-1 | 129.6±10.4 | 170.2±16.4# | 167.6±13.8¶ | 178.6±13.8+ |
FVC L | 3.51±0.35 | 3.45±0.24 | 3.42±0.13 | 3.43±0.28 |
FEV1 % pred | 90.7±2.4 | 89.5±2.3 | 88.9±2.8 | 87.9±3.0 |
AHI events·h-1 | 3.4±0.5 | 4.0±0.3 | 9.8±2.0¶,§ | 46.5±9.8+,ƒ,## |
Sa,O2<90% %TST | 0 | 0 | 4.1±3.1¶,§ | 38.9±12.9+,ƒ,## |
Lowest Sa,O2 % | 96.0±2.0 | 96.4±1.8 | 83.6±6.0¶,§ | 70.9±7.9+,ƒ,## |
Arousal index events·h-1 | 13.9±7.7 | 15.4±9.8 | 18.4±4.0¶,§ | 42.3±6.8+,ƒ,## |
TST min | 403.9±90.2 | 411.9±100.1 | 380.0±35.4¶,§ | 328.0±68.1+,ƒ,## |
ESS | 7.3±0.4 | 8.2±0.5 | 9.8±0.7¶ | 13.1±2.8+,ƒ,## |
Data are presented as mean±sem, unless otherwise stated. BMI: body mass index; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FVC: forced vital capacity; FEV1: forced expiratory volume in one second; % pred: percentage of predicted; AHI: apnoea–hypopnoea index; Sa,O2: arterial oxygen saturation; TST: total sleep time; ESS: Epworth Sleepiness Scale. #: p<0.01 healthy control versus obese control; ¶: p<0.01 healthy control versus mild OSA; +: p<0.01 healthy control versus moderate-to-severe OSA; §: p<0.01 obese control versus mild OSA; ƒ: p<0.01 obese control versus moderate-to-severe OSA; ##: p<0.01 mild OSA versus moderate-to-severe OSA.