Study selection criteria | Results | ||||||||||
SNP | Pheno. | Ethnicity | Control groups | Multiple control groups# | Assoc. | Cases | Controls | Heterozygote | Homozygote | ||
OR | p-value | OR | p-value | ||||||||
EPHX1 Tyr113His | B | B | B | Yes | 5 | 500 | 725 | 0.95 | 0.80 | 0.79 | 0.20 |
C | B | B | No | 2 | 279 | 381 | 1.28 | 0.15 | 0.50 | 0.03 | |
E | A | S | No | 2 | 142 | 230 | 0.61 | 0.07 | 0.93 | 0.80 | |
EPHX1 His139Arg | B | B | B | Yes | 9 | 829 | 1282 | 1.15 | 0.18 | 1.30 | 0.32 |
C | B | B | No | 6 | 577 | 907 | 1.2 | 0.21 | 1.17 | 0.61 | |
C | Ca | B | No | 3 | 397 | 613 | 1.36 | 0.19 | 1.00 | 0.99 | |
C | A | H | No | 3 | 180 | 294 | 0.97 | 0.90 | 1.58 | 0.48 | |
E | B | B | Yes | 3 | 252 | 375 | 1.06 | 0.75 | 1.55 | 0.32 | |
TNF G-308A | B | B | B | Yes | 9 | 881 | 1232 | 1.25 | 0.22 | 0.67 | 0.02 |
C | B | B | Yes | 8 | 818 | 1146 | 1.31 | 0.17 | 0.66 | 0.07 | |
C | B | S | No | 5 | 527 | 513 | 1.23 | 0.43 | 0.81 | 0.12 | |
C | B | H | No | 3 | 291 | 633 | 1.49 | 0.31 | 0.32 | <0.001 | |
C | A | B | Yes | 3 | 137 | 206 | 5.05 | <0.001 | 0.55 | 0.06 | |
C | Ca | B | Yes | 5 | 681 | 940 | 1.01 | 0.90 | 0.96 | 0.91 |
Data are presented as n, unless otherwise stated. Pheno.: phenotype; Assoc.: association; OR: odds ratio; B: both; C: COPD; E: emphysema; A: Asian; Ca: Caucasian; S: smoking; H: healthy. #: some studies had multiple control groups; if “yes”, each association between cases and different control groups was used, thus counting cases twice.