Table 3—

The initial empirical antimicrobial choice according to adequacy of treatment and baseline severity of illness, as measured by pneumonia severity index(PSI) score, and its relation to mortality

Empirical therapeutic optionPatients n (%)Concordant treatment#PSI score I–IIIPSI score IV, V
Patients30-day mortalityPatients30-day mortality+
β-Lactams+macrolides198 (31)94.4 (90.3–97.2)72 (36.4, 29.7–43.5)6 (8.3, 3.1–17.3)126 (63.6, 56.5––70.3)25 (19.8, 13.3–27.9)
β-Lactams251 (39.3)86.5 (82.2– 90.7)109 (43.4, 37.3–49.6)2 (1.8, 0.2–6.5)142 (56.6, 50.4–62.7)25 (17.6, 11.7– 24.9)
Macrolides37 (5.8)64.9 (47.5–79.8)24 (64.9, 47.5–79.8)1 (4.2, 0.1– 21.1)13 (35.1, 20.2–52.5)0
Levofloxacin (mono/polytherapy)48 (7.5)100 (92.6– 100)22 (45.8, 31.4–60.8)026 (54.2, 39.2– 68.6)2 (7.7, 0.9–25.1)
Other combinations104 (16.3)80.8 (71.9– 87.8)30 (28.8, 20.4–38.6)1 (3.3, 0.1–17.2)74 (71.2, 61.4–79.6)30 (40.5, 29.3– 52.6)
638 (100)87.8 (85.2– 90.3)257 (40.3, 36.5–44.1 )10 (3.9, 1.8– 7)381 (59.7, 55.9–63.5)82 (21.5, 17.4– 25.6)
  • Data are presented as n (%), n (95% confidence intervals (%)) or n (%, 95% CI). Antibiotic treatment was considered concordant if at least one antibiotic administered during the first 48 h after the specimen was obtained for culture showed full in vitro sensitivity (neither intermediate nor resistant) against the isolated strains. #: p<0.0001; : p = 0.203; +: p = 0.001.