Table 1—

Estimates of the protease inhibitor(PI)*S and PI*Z gene frequency and phenotype prevalence of each of the five phenotypic classes in the 21 European countries studied

Country total populationn#Calculated frequency × 1000Calculated prevalence 1/×(Hardy-Weinberg)Calculated prevalence 1/×(Hardy-Weinberg)Total PI*S and PI*Z calculated prevalence 1/×(Hardy-Weinberg)
PI*SPI*ZPI MZPI SZPI ZZPI MSPI SS
Austria 8174762868 (6.4)20 (14–28)13 (9–20)1/39 (25–61)1/1872 (879–4062)1/5697 (2464–13478)1/26 (18–37)1/2460 (1254–4897)1/15
Belgium 103482761345 (10.8)54 (46–63)16.7 (12–22)1/32 (24–44)1/551 (349–876)1/3573 (1972–6539)1/10 (8–12)1/339 (247–469)1/7
Denmark 54133921096 (12)28 (25–30)27 (24–29)1/20 (18–21)1/663 (562–783)1/1368 (1157–1617)1/19 (17–21)1/1286 (1091–1517)1/9
Estonia 13416641850 (6.5)12.7 (9–17)24 (19–29)1/22 (17–27)1/1636 (992–2718)1/1636 (992–2718)1/41 (30–55)1/6197 (3459–1198)1/14
Finland 52145122112 (4.3)7 (5–10)6.6 (4–9.7)1/76 (52–113)1/10278 (4890–21916)1/22758 (10621–49527)1/69 (48–100)1/18566 (9007–38792)1/36
France 604242138753 (8.3)76 (72–80)12.8 (11–14.6)1/43 (37–49)1/512 (426–615)1/6054 (4652–7886)1/7 (7–8)1/173 (156–192)1/6
Germany 824246095886 (5.1)21 (18–23)9.8 (8–11.8)1/52 (43–63)1/2418 (1774–3302)1/10299 (7120–14931)1/25 (22–28)1/2271 (1769–2920)1/16
Hungary 100323751036 (5.9)25 (19–33)6.7 (3.8–11)1/76 (44–135)1/2949 (1304–6844)1/21904 (7418–67495)1/1588 (916–2776)1/21 (16–27)1/16
Italy 5805747712239 (7.6)23 (21–25)16 (15–18)1/32 (29–35)1/1336 (1115–1601)1/3708 (3048–4513)1/23 (21–25)1/1924 (1631–2272)1/13
Latvia 2306306288 (5.6)31 (19–50)45 (30–60)1/12 (8–18)1/354 (151–861)1/491 (227–1091)1/17 (11–29)1/1024 (402–2718)1/7
Lithuania 36078991995 (6.4)17 (13–21)15 (12–19)1/34 (26–45)1/1980 (1201–3284)1/4422 (2644–7443)1/31 (24–40)1/3546 (2182–5797)1/16
The Netherlands 163181992539 (4.8)21 (18–26)10 (7.7–13)1/50 (38–67)1/2275 (1427–3646)1/9536 (5475–16725)1/24 (20–29)1/2170 (1487–3179)1/16
Norway 45745604492 (8.2)25 (21–28)18 (16–21)1/28 (24–33)1/1095 (824–1458)1/2929 (2156–3986)1/21 (18–24)1/1638 (1258–2134)1/12
Poland 386263499539 (4.9)15 (13–17)4 (3–5)1/123 (98–155)1/8169 (5800–11529)1/58319 (37177–91784)1/34 (31–39)1/4577 (3619–5792)1/27
Portugal 105241451449 (6.2)129 (117–141)13.8 (10–19)1/42 (30–59)1/281 (186–428)1/5249 (2788–9987)1/5 (4–5)1/60 (50–73)1/4
Russia 1437823382787 (3.5)10 (7–13)3 (2–5)1/149 (93–241)1/15141 (7243–32167)1/86065 (33951–23894)1/52 (40–69)1/10655 (6181–18486)1/38
Serbia 108259001060 (5.1)7 (4–11)12.7 (8–18)1/40 (27–60)1/5945 (2350–15500)1/6165 (2846–13600)1/77 (45–137)1/22931 (7764–70661)1/26
Spain 402807802458 (7.7)104 (96–113)17 (14–21)1/33 (26–41)1/278 (206–375)1/3334 (2175–5164)1/5 (5–6)1/92 (78–109)1/4
Sweden 89864001062 (8.81)24 (18–32)23 (17–30)1/23 (17–31)1/885 (506–1562)1/1879 (1066–3345)1/21 (16–29)1/1668 (963–2917)1/11
Switzerland 74508671148 (8.1)38 (31–47)11 (7–17)46 (31–70)1152 (630–2131)7798 (3544–17485)14 (11–17)681 (448–1039)1/10
UK 602707084775 (6.5)27 (24–31)12 (10–14)44 (36–53)1533 (1127–2088)7018 (4838–10205)19 (17–22)1339 (1051–1708)1/13
European totals75390 (6.9)33 (32–34)14.5 (14–15)1/36 (35–38)1/1051 (980–1126)1/4727 (4348–5139)1/16 (16–17)1/934 (884–987)1/11
  • Data are presented as n (95% confidence interval), unless otherwise stated. #: number of subjects (mean precision factor score); : numbers in parentheses represent 95% confidence interval.