Table 1—

Approved fungal allergens

Protein classificationNamed allergen
Protein synthesis/secretion
 Elongation factor 1β#Pen c24 (A2K12; A. fumigatus)
 Eukaryote initiation factor-2 α-kinase#Alt a2
 Cyclophilin#Asp f11, Cand a CyP, Psi c2, Sac c CyP, Mala s6
 HSP70#Asp f12, Alt a3, Cla h HSP70, Pen c19, Mala s10
 Cold shock proteinCla h8
 Disulphideisomerases#Alt a4
 Acid ribosomal protein P1#Alt a12, Cla h12
 Acid ribosomal protein P2#Asp f8, Alt a6, Cla h4, Fus c1
Stress response
 Peroxisomal membrane protein#Asp f3, Cand a2, Cand b2, Mala f2, Mala f3 Mala s1
 ThioredoxinCop c2, Fus c2
 YCP4 protein, similar to flavodoxinsAlt a7, Cla h5
 MnSOD#Asp f6, Sac c MnSOD, Mala s11
Proteases/toxins
 RibotoxinAsp f1
 Vacuolar serine protease, cerevisin#Asp f18, Asp fl18, Asp n18, Pen c2, Pen c18, Pen ch18, Pen o18, Rho m2
 Acid proteaseCAAP
 Alkaline serine protease, oryzinAsp f13, Asp fl13, Pen b13, Pen c13, Tri r2, Asp fl1, Asp o13, Cur l1, Epi p1, Pen c1, Tri r4, Tri t4
 Aspartic protease#Asp f10
 MetalloproteaseAsp f5
Enzymes of gluconeogenesis from lipid
 Aldehyde/alchohol dehydrogenaseAlt a10, Cla h3, Cand a1
 Malate dehydrogenaseMala f4
 Enolase#Asp f22, Alt a5, Alt a11, Cand a enolase, Cla h6, Pen c22, Rho m1, Sac c enolase
Glycosidases
 β-glucanase (family 16)Asp f2 Asp f9, Asp f16, Asp f17, Tri t1, Asp n1
 Glycosyl hydrolase (cellulase)Sta c cellulase, Asp f4, Asp f7, Asp n hemicellulase
 β-XylosidaseAsp n14
 3-Phytase BAsp n25
 GlucoamylaseAsp n glucoamylase
 TAKA-amylase AAsp o21, Asp o2
N-Acetyl glucosaminidasePen ch20
 β-GalactosidaseAsp o lactase
 Glycoprotein Ag-54Cla h2
Others
 Nuclear transport factor 2#Alt a NTF2, Cla h NTF2
 LipaseThe l1
 Hydrophobin (conidia)Cla h HCh-1
 Leucine zipper proteinCop c1
 Unknown functionFus c3, Fus s45kD, Fus s1, Cop c3, Cop c5, Cop c7, Cop c6, Cop c4, Psi c1, Alt a70kD, Alt a1, Alt b1, Alt a8, Alt a9, Cla h1, Cla h7, Cla h9
  • Alt a: Alternaria alternata; Alt b: Alternaria brassicola; Asp f: Aspergillus fumigatus; Asp fl: Aspergillus flavus; Asp n: Aspergillus niger; Asp o: Aspergillus oryzae; Cand a: Candida albicans, Cand b: Candida boidinii; Cla h: Cladosporium herbarum; Cop c: Coprinus comatus; Cur l: Curvularia lunata; Epi p: Epicoccum nigrum; Fus c: Fusarium culmorum; Fus s: fusarium solani; Mala f: Malassezia furfur, Mala s: Malasezzia sympodialis; Pen b: Penicillium brevicompactum; Pen c: Penicillium citrinum; Pen ch: Penicillium chrysogenum; Pen o: Penicillium oxalicum; Psi c: Psilocybe cubensis; Rho m: Rhodotorula mucilaginosa; Sac c: Saccharomyces cerevisiae; Sta c: Stachybotris chartarum; The l: Thermonyces lanuginosus; Tri r: Trichophyton rubrum; Tri t: Trichophyton tonsurans; CAAP: Candida albicans alkaline protease; CyR: cyclophilin; HCL-1: hydrohobin; HSP: heat shock protein; MnSOD: manganese superoxide dismutase; Ag: antigen; NTF: nuclear transport factor. #: proteins with significant levels of mammalian homology (better than 1E−30, basic local alignment search tool (BLAST) score >200, percentage identity >30%); : as used in detergents.