Table 2—

Eicosanoid metabolites and plasma P-selectin after drug administration

Variable	Placebo	ASA	Clopidogrel	p-value
Variable	Placebo	ASA	Clopidogrel	ASA versus placebo	Clopidogrel versus placebo	ASA versus clopidogrel
Serum TxB₂ ng·mL⁻¹	63±9	13±9	59±9	<0.0001	0.75	0.0003
Urine Tx-M ng·mg Cr⁻¹	0.33±1.1	0.09±1.1	0.32±1.1	<0.0001	0.44	<0.0001
Urine PGI-M ng·mg Cr⁻¹	2.6±0.6	2.4±0.5	3.2±0.6	0.68	0.45	0.24
Urine Tx-M/PGI-M	0.46±1.2	0.16±1.2	0.42±1.2	<0.0001	0.68	<0.0001
Plasma P-selectin ng·mL⁻¹	35±2	31±2	31±2	0.05	0.09	0.85

Data are presented as least squares mean±se after adjustment for period, sequence, centre, epoprostenol use and the drug by epoprostenol interaction. ASA: aspirin; TxB₂: thromboxane B₂; Tx-M: 11-dehydro-thromboxane B₂; Cr: creatinine; PGI-M: 2,3-dinor-6-keto-prostaglandin F_1α.